Potential Role of the Microbiome in Acne: A Comprehensive ReviewYoung Bok Lee 1 , Eun Jung Byun 2 and Hei Sung Kim 2,3,* 1 Department of Dermatology, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, Korea 2 Department of Dermatology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Seoul 06591, Korea 3 Department of Biomedicine & Health Sciences, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea * Correspondence: hazelkimhoho@gmail.com; Tel.: +82-32-280-5105 3줄 요약* 말라세지아(Malassezia | A.K.A 좁쌀 여드름 유발균 중 하나)는 여드름 시작의 원인으로 오래 전부터 알려져있다.* 난치성 여드름은 C.Acne 보다는 말라세지아와 연관되어 있다고 알려져있다.* 말라세지아는 피지를 분해하여 모공 내의 지방산을 증가시켜 좁쌀여드름(면포)을 유발하고, 또한 염증을 증가시키는 것으로 알려져있다. 결론 :: 모공 내의 지방산이 증가하게 되면 좁쌀여드름 그리고 피부 내 염증이 증가할 수 있다. [ 관련 이미지 ] [ 원문 발췌 ]Acne is a highly prevalent inflammatory skin condition involving sebaceous sties. Although it clearly develops from an interplay of multiple factors, the exact cause of acne remains elusive. It is increasingly believed that the interaction between skin microbes and host immunity plays an important role in this disease, with perturbed microbial composition and activity found in acne patients. Cutibacterium acnes (C. acnes; formerly called Propionibacterium acnes) is commonly found in sebum-rich areas and its over-proliferation has long been thought to contribute to the disease. However, information provided by advanced metagenomic sequencing has indicated that the cutaneous microbiota in acne patients and acne-free individuals di er at the virulent-specific lineage level. Acne also has close connections with the gastrointestinal tract, and many argue that the gut microbiota could be involved in the pathogenic process of acne. The emotions of stress (e.g., depression and anxiety), for instance, have been hypothesized to aggravate acne by altering the gut microbiota and increasing intestinal permeability, potentially contributing to skin inflammation. Over the years, an expanding body of research has highlighted the presence of a gut–brain–skin axis that connects gut microbes, oral probiotics, and diet, currently an area of intense scrutiny, to acne severity. This review concentrates on the skin and gut microbes in acne, the role that the gut–brain–skin axis plays in the immunobiology of acne, and newly emerging microbiome-based therapies that can be applied to treat acne.Keywords: acne; microbiota; microbiome; skin; gut; brain; therapeutic implications [ 전문 보기(Click) ]
